The ENDOTHELIUM Association
All heart attacks and most strokes are caused by a sick endothelium
Nobody suspected that heart attacks and strokes might
originate with the arterial endothelium (the inner lining)
until Dr. Robert Furchgott ran a series of arterial experi-
ments. He found that there was a mysterious factor
causing the arteries to relax. He called it the Endothelium
Derived Relaxant Factor or EDRF, Dr. Louis Ignarro
discovered that EDRF was, nitric oxide (NO), which the
endothelium produced and delivered to the artery
walls. Dr.Ferid Murad, also a Nobel winner, discovered
that the reason nitroglycerin pills were helpful to people
with angina was that nitroglycerin caused a massive re-
lease of NO by the body.This relaxed the arteries, allowing
more blood flow, which in turn, eliminated the pain in the
chest. The researchers further found that there was an
unknown signaling system between the artery walls and
the endothelium. Their discoveries led to the 1998 Nobel
Prize for Physiology and Medicine. The key insight into the
heart attack and stroke occurence had been found.
About 60 % of all heart attacks happen without a warning of any kind. If you are eating a normal
American diet, you are a candidate for a heart attack or a stroke.
YouTube Heart attack proofing yourself Dr. Caldwell B. Esselstyn, Cleveland Clinic More Info
You can choose not to be a candidate by using some of the information these Nobel scientists and others have
discovered. To make an informed choice, read on. Here is some of the key information and sources you need..
SEE THE ANGIOGRAM BELOW
The coronary artery on the left was inoperable. The patient, a doctor at the
Cleveland Clinic, went on a vegetarian diet. Shortly after going on the diet, all
angina symptoms were eliminated .This is what happened to his coronary artery in
32 months. The results are clear. He is now fully functional.
The endothelium wants to get better. Give it a chance.
Angiograms courtesy of Caldwell H. Esselstyn, Jr. M.D. - Cleveland Clinic
We know that diet is the key factor because:
1. Heart attacks and strokes are unknown in societies throughout the world that
are living on a vegetable based diet.
2. When populations, formerly on a vegetable diet, move towards a Western diet,
they start getting heart attacks and strokes.
3. For many years, the few doctor in the US who have used a dietary approach,
have had long term success helping patients to full recovery, even patients near
Source Esselstyn Ornish Whitaker
4. The German WWII diet experiment in Norway and the Low Countries
Source Esselstyn MORE
Over time, the endothelium becomes sicker and more inflamed on a Western diet. . MORE
A sick endothelium, to protect itself, invites white cells into itself and the artery wall. When it does this, it
gives up its impenetrable quality and becomes like Velcro, to which everything sticks. Thus the artery walls start
collecting. Wall build ups occur. This leads to arteriosclerosis, hardening of the arteries and a progressive narrowing
of the arteries. Source Cooke MORE
The sick artery wall develops a condition somewhat like acne with boils: when a boil breaks, there is either a heart
attack or stroke. MORE
The endothelium wants to get healthy. Feed it what it wants and it will take
care of you - at any age!!
This website does not provide medical advice. The website is for information
For medical advice, consult your healthcare provider
The arterial endothelium, which lines the arteries, plays the key role in
keeping your arteries healthy by doing five things:
1. It makes the artery walls like Teflon so that nothing can stick to them.
2. It receives signals from the artery wall requesting nitric oxide (NO).
3. It makes NO from the amino acid L-arginine.
4. It delivers NO to the specific artery wall in need of NO.
5. It repairs a sick or damaged arterial system. MORE
Source Aird Cooke Esselstyn Ignarro Ornish Sinatra Whitaker
NO plays the critical role of keeping the arteries soft and flexible - which
allows the arteries to easily expand and thus pass more blood with less effort by
Source Cooke Esselstyn Ignarro Sinatra MORE
L-arginine, as the basic building block for NO, must be available in
sufficient quantity if the endotlelium is to supply the requested NO. MORE
Source Cooke Esselstyn Ignarro Sinatra
Our Western meat diet, which irritates the endothelium, is the primary
reason endotheliums get sick and inflamed although smoking, diabetes and
over weight are also very important factors.
Source Cooke Esselstyn Ignarro Ornish Sinatra Whitaker
HELEN AND PHIL
It is far better to still be able to do
the things we have always enjoyed.